The only issue I am aware of is that latency inducing plugins in the prefader slot offset the playback of audio such that the automation is early to the audio by the amount of the latency. SS keeps the appropriate buffer delay for on/off of plugins, but the automation is displaced by the prefader latency. So, I have come to only use non latency plugins in the pre slot, but all latency inducing ones in the post fader slot.
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