The Mouse is USB 1 or at best USB 2 (nobody is building USB3 mice). The difference is going to be how the physical USB hub is physically wired/structured. USB 3 and USB 1/2 devices utilize different pins on the port, and CAN apparently be structured to segregate the USB 3 and USB 1/2 bandwidth allocations. So depending on how the Hub has be designed will determine how much effect USB 1/2 devices will have on the USB 3 bandwidth.
If a hub is not being used and those devices are being plugged into different USB ports on the computer, than the bandwidth limitations will depend on if the two ports share a common or different USB bus channel.
If they are shared then you will see bandwidth limitations. If they are different, then the two ports operate independently.
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